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KMID : 1140120060110010030
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Cancer Prevention Research
2006 Volume.11 No. 1 p.30 ~ p.38
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Effect of S9940, an Inhibitor of Exocytosis on Neurite Extension in Rat Hippocampal Neurons and PC12 Cells
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Lee Yun-Sik
Kim Chong-Wook
Jhee Ok-Hwa
Om Ae-Son
Kang Ju-Seop
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Abstract
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We identified S8877, a novel microbial metabolite from Streptomyces spp., to inhibit the release of neurotransmitter form rat hippocampal neuron and PC12 cells. S8877 is an inhibitor of trifiated norepinephrine ([3H]-NE) release in high K buffer solution containing ionomycin, indicating that S8877 inhibits neurotransmitter release after the influx of Ca2 ions. We also examined the effect of S8877 on β-glucuronidase release from guinea pig neurophils and on the neurite extension of rat hippocampal neurons and PC12 cells. As a result, S8877 increased β-glucruonidas release: when treated with 5μg/ml of S8877, which prevented [3H]-NE release, and the inhibition of neurite extension for both rat hippocampal neurons and PC12 cells was observed.
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KEYWORD
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Neuron, Exocytosis, Inhibitor, Neurophil, β-glucuronidas
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